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SERBP1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NC51 |
|---|
| Gene ID | 26135 |
|---|---|
| Other Names | Plasminogen activator inhibitor 1 RNA-binding protein, PAI1 RNA-binding protein 1, PAI-RBP1, SERPINE1 mRNA-binding protein 1, SERBP1, PAIRBP1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 149-163 of HUMAN SERBP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SERBP1 {ECO:0000303|PubMed:36691768, ECO:0000312|HGNC:HGNC:17860} |
|---|---|
| Function | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A- site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, perinuclear region |
| Tissue Location | Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.
References
Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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