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MOUSE Brd7 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O88665 |
|---|
| Gene ID | 26992 |
|---|---|
| Other Names | Bromodomain-containing protein 7, 75 kDa bromodomain protein, Brd7, Bp75 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 387-398 of HUMAN Brd7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Brd7 |
|---|---|
| Synonyms | Bp75 |
| Function | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down- regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q9NPI1} |
| Tissue Location | Ubiquitous.. |
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Background
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24- mediated activation of transcriptional activation by AR.
References
Cuppen E.,et al.FEBS Lett. 459:291-298(1999).
Carninci P.,et al.Science 309:1559-1563(2005).
Kim S.,et al.Cancer Res. 63:4792-4795(2003).
Kaeser M.D.,et al.J. Biol. Chem. 283:32254-32263(2008).
Kikuchi M.,et al.Biochim. Biophys. Acta 1793:1828-1836(2009).
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