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MOUSE Brd7 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O88665
Additional Information
Gene ID 26992
Other Names Bromodomain-containing protein 7, 75 kDa bromodomain protein, Brd7, Bp75
Target/Specificity The synthetic peptide sequence is selected from aa 387-398 of HUMAN Brd7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Brd7
Synonyms Bp75
Function Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24- mediated activation of transcriptional activation by AR.
Cellular Location Nucleus
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24- mediated activation of transcriptional activation by AR.

References

Cuppen E.,et al.FEBS Lett. 459:291-298(1999).
Carninci P.,et al.Science 309:1559-1563(2005).
Kim S.,et al.Cancer Res. 63:4792-4795(2003).
Kaeser M.D.,et al.J. Biol. Chem. 283:32254-32263(2008).
Kikuchi M.,et al.Biochim. Biophys. Acta 1793:1828-1836(2009).

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$ 80.00
Cat# BP20823c
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