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Mouse Kdm6b Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q5NCY0
Additional Information
Gene ID 216850
Other Names Lysine-specific demethylase 6B, 11411-, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, Kdm6b, Jmjd3, Kiaa0346
Target/Specificity The synthetic peptide sequence is selected from aa 1023-1037 of HUMAN Kdm6b
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Kdm6b
Synonyms Jmjd3, Kiaa0346
Function Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

References

Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Okazaki N.,et al.DNA Res. 10:167-180(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
De Santa F.,et al.Cell 130:1083-1094(2007).

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$ 80.00
$ 99.00
Cat# BP20854c
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