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LAPTM4B-3 Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86VI4
Additional Information
Gene ID 55353
Other Names Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta, LAPTM4B
Target/Specificity The synthetic peptide sequence is selected from aa 80-94 of HUMAN LAPTM4B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAPTM4B (HGNC:13646)
Function Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
Cellular Location Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen
Research Areas
Citations (0)

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References

Shao G.-Z.,et al.Oncogene 22:5060-5069(2003).
Hogue D.L.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Wiemann S.,et al.Genome Res. 11:422-435(2001).

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$ 80.00
Cat# BP20870a
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