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PAX6 Blocking Peptide (Center)

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession P26367
Other Accession P63015, P26630, Q1LZF1
Additional Information
Gene ID 5080
Other Names Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2
Target/Specificity The synthetic peptide sequence is selected from aa 183-194 of HUMAN PAX6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX6
Synonyms AN2
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Cellular Location Nucleus.
Tissue Location Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form
Research Areas
Citations (0)

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Background

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

References

Ton C.C.T.,et al.Cell 67:1059-1074(1991).
Glaser T.,et al.Nat. Genet. 2:232-239(1992).
Liu J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 80.00
$ 99.00
Cat# BP20979a
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