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MAPT Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P10636
Other Accession P19332, P10637, P29172
Additional Information
Gene ID 4137
Other Names Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
Target/Specificity The synthetic peptide sequence is selected from aa 694-708 of HUMAN MAPT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAPT
Synonyms MAPTL, MTBT1, TAU
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
Tissue Location Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system
Research Areas
Citations (0)

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Background

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

References

Goedert M.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
Goedert M.,et al.EMBO J. 8:393-399(1989).
Lee G.,et al.Neuron 2:1615-1624(1989).
Goedert M.,et al.Neuron 3:519-526(1989).
Andreadis A.,et al.Biochemistry 31:10626-10633(1992).

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$ 80.00
$ 99.00
Cat# BP20990c
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