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Mouse Hes1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P35428
Other Accession Q04666, Q14469
Additional Information
Gene ID 15205
Other Names Transcription factor HES-1, Hairy and enhancer of split 1, Hes1, Hes-1
Target/Specificity The synthetic peptide sequence is selected from aa 205-219 of HUMAN Hes1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Hes1
Synonyms Hes-1
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds
Research Areas
Citations (0)

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Background

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).

References

Takebayashi K.,et al.J. Biol. Chem. 269:5150-5156(1994).
Grbavec D.,et al.Eur. J. Biochem. 258:339-349(1998).
Bae S.-K.,et al.Development 127:2933-2943(2000).

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$ 80.00
$ 99.00
Cat# BP21019c
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