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PRDM14 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9GZV8
Additional Information
Gene ID 63978
Other Names PR domain zinc finger protein 14, 211-, PR domain-containing protein 14, PRDM14
Target/Specificity The synthetic peptide sequence is selected from aa 128-143 of HUMAN PRDM14
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDM14
Function Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Cellular Location Nucleus.
Tissue Location Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level)
Research Areas
Citations (0)

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Background

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

References

Yang X.-H.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nishikawa N.,et al.Cancer Res. 67:9649-9657(2007).
Chia N.Y.,et al.Nature 468:316-320(2010).
Rigbolt K.T.,et al.Sci. Signal. 4:RS3-RS3(2011).

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$ 80.00
Cat# BP21051a
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