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(Mouse) Pdx1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P52946
Additional Information
Gene ID 18609
Other Names Pancreas/duodenum homeobox protein 1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox 1, IDX-1, Somatostatin-transactivating factor 1, STF-1, Pdx1, Ipf1
Target/Specificity The synthetic peptide sequence is selected from aa 136-149 of HUMAN Pdx1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pdx1
Synonyms Ipf1
Function Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:17052199}. Cytoplasm, cytosol
Tissue Location Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells)
Research Areas
Citations (0)

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Background

Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.

References

Ohlsson H.,et al.EMBO J. 12:4251-4259(1993).
Carninci P.,et al.Science 309:1559-1563(2005).
Swift G.H.,et al.Mol. Cell. Biol. 18:5109-5120(1998).
Liu Y.,et al.J. Biol. Chem. 276:17985-17993(2001).
Liu A.,et al.Mol. Cell. Biol. 24:4372-4383(2004).

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$ 80.00
$ 99.00
Cat# BP21086a
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