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LMCD1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9NZU5
Additional Information
Gene ID 29995
Other Names LIM and cysteine-rich domains protein 1, Dyxin, LMCD1
Target/Specificity The synthetic peptide sequence is selected from aa 316-330 of HUMAN LMCD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMCD1
Function Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Cellular Location Cytoplasm. Nucleus. Note=May shuttle between the cytoplasm and the nucleus.
Tissue Location Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.
Research Areas
Citations (0)

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Background

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

References

Bespalova I.N.,et al.Genomics 63:69-74(2000).
Holt H.H.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Rath N.,et al.Mol. Cell. Biol. 25:8864-8873(2005).
Bian Z.Y.,et al.Hypertension 55:257-263(2010).

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$ 80.00
$ 99.00
Cat# BP21108a
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