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UBE2D1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P51668
Other Accession NP_003329
Clone Names 3061601
Peptide ID 3061601
Additional Information
Gene ID 7321
Other Names Ubiquitin-conjugating enzyme E2 D1, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1, UBE2D1, SFT, UBC5A, UBCH5, UBCH5A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2112b was selected from the C-term region of human UBE2D1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2D1
Synonyms SFT, UBC5A, UBCH5, UBCH5A
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.


Bres, V., et al., Nat. Cell Biol. 5(8):754-761 (2003).Gehrke, S.G., et al., Blood 101(8):3288-3293 (2003).Kamura, T., et al., Proc. Natl. Acad. Sci. U.S.A. 97(19):10430-10435 (2000).Gutierrez, J.A., et al., Biochem. Biophys. Res. Commun. 253(3):739-742 (1998).Jensen, J.P., et al., J. Biol. Chem. 270(51):30408-30414 (1995).

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$ 80.00
Cat# BP2112b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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