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DOCK2 Blocking Peptide (C-term)

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession Q92608
Additional Information
Gene ID 1794
Other Names Dedicator of cytokinesis protein 2, DOCK2, KIAA0209
Target/Specificity The synthetic peptide sequence is selected from aa 1812-1826 of HUMAN DOCK2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOCK2
Synonyms KIAA0209
Function Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Cellular Location Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin
Tissue Location Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon
Research Areas
Citations (0)

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Background

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.

References

Nagase T.,et al.DNA Res. 3:321-329(1996).
Nishihara H.,et al.Biochim. Biophys. Acta 1452:179-187(1999).
Nishihara H.,et al.Blood 100:3968-3974(2002).
Nishihara H.,et al.Biochem. Biophys. Res. Commun. 296:716-720(2002).
Cote J.-F.,et al.J. Cell Sci. 115:4901-4913(2002).

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$ 80.00
$ 99.00
Cat# BP21150a
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