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DOCK2 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92608 |
|---|
| Gene ID | 1794 |
|---|---|
| Other Names | Dedicator of cytokinesis protein 2, DOCK2, KIAA0209 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1812-1826 of HUMAN DOCK2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DOCK2 |
|---|---|
| Synonyms | KIAA0209 |
| Function | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. |
| Cellular Location | Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin |
| Tissue Location | Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
References
Nagase T.,et al.DNA Res. 3:321-329(1996).
Nishihara H.,et al.Biochim. Biophys. Acta 1452:179-187(1999).
Nishihara H.,et al.Blood 100:3968-3974(2002).
Nishihara H.,et al.Biochem. Biophys. Res. Commun. 296:716-720(2002).
Cote J.-F.,et al.J. Cell Sci. 115:4901-4913(2002).
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