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GNAI3 Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P08754
Additional Information
Gene ID 2773
Other Names Guanine nucleotide-binding protein G(k) subunit alpha, G(i) alpha-3, GNAI3
Target/Specificity The synthetic peptide sequence is selected from aa 309-323 of HUMAN GNAI3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNAI3
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Cellular Location Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody
Research Areas
Citations (0)

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Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

References

Didsbury J.R.,et al.FEBS Lett. 219:259-263(1987).
Beals C.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7886-7890(1987).
Itoh H.,et al.J. Biol. Chem. 263:6656-6664(1988).
Codina J.,et al.J. Biol. Chem. 263:6746-6750(1988).
Kim S.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4153-4157(1988).

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$ 80.00
$ 99.00
Cat# BP21247a
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