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Mouse Neurog2 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P70447
Additional Information
Other Names Neurogenin-2, NGN-2, Helix-loop-helix protein mATH-4A, mATH4A, Protein atonal homolog 4, Neurog2, Ath4a, Atoh4, Ngn2
Target/Specificity The synthetic peptide sequence is selected from aa 247-262 of HUMAN Neurog2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Neurog2
Synonyms Ath4a, Atoh4, Ngn2
Function Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981} EMBL; U76207; AAC53028.1; -; Genomic_DNA EMBL; Y07621; CAA68900.1; -; mRNA EMBL; AF303001; AAG40769.1; -; Genomic_DNA CCDS; CCDS17825.1; - RefSeq; NP_033848.1; NM_009718.2 UniGene; Mm.42017; - ProteinModelPortal; P70447; - SMR; P70447; - BioGrid; 198240; 4 STRING; 10090.ENSMUSP00000029587; - iPTMnet; P70447; - PhosphoSitePlus; P70447; - PaxDb; P70447; - PRIDE; P70447; - GeneID; 11924; - KEGG; mmu:11924; - CTD; 63973; - MGI; MGI:109619; Neurog2 eggNOG; ENOG410IQ4B; Eukaryota eggNOG; ENOG410XZ4C; LUCA HOGENOM; HOG000063655; - HOVERGEN; HBG101129; - InParanoid; P70447; - KO; K09082; - PRO; PR:P70447; - Proteomes; UP000000589; Unplaced CleanEx; MM_NEUROG2; - GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0070888; F:E-box binding; IDA:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI GO; GO:0007411; P:axon guidance; IMP:MGI GO; GO:0045165; P:cell fate commitment; IGI:MGI GO; GO:0048469; P:cell maturation; IMP:MGI GO; GO:0021954; P:central nervous system neuron development; IMP:MGI GO; GO:0030900; P:forebrain development; IMP:MGI GO; GO:0022008; P:neurogenesis; IDA:MGI GO; GO:0030182; P:neuron differentiation; IMP:MGI GO; GO:0001764; P:neuron migration; IMP:MGI GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; IDA:UniProtKB GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032655; Ngn2 PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 263 Neurogenin-2 /FTId=PRO_0000127401 DOMAIN 112 164 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} CONFLICT 60 60 E -> G (in Ref. 2; CAA68900) SEQUENCE 263 AA; 28216 MW; 817EF8246BD8CABE CRC64; MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH RYAPHLPLAR DCI
Research Areas
Citations (0)

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Background

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

References

Sommer L.,et al.Mol. Cell. Neurosci. 8:221-241(1996).
Gradwohl G.,et al.Dev. Biol. 180:227-241(1996).
Simmons A.D.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Lin C.H.,et al.Dev. Biol. 265:234-245(2004).

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$ 80.00
Cat# BP21257b
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