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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   FKBP1A Blocking Peptide (Center)   

FKBP1A Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P62942
Additional Information
Gene ID 2280
Other Names Peptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12, Calstabin-1, FK506-binding protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase, FKBP1A, FKBP1, FKBP12
Target/Specificity The synthetic peptide sequence is selected from aa 34-48 of HUMAN FKBP1A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP1A
Synonyms FKBP1, FKBP12
Function Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

References

Maki N.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5440-5443(1990).
Standaert R.F.,et al.Nature 346:671-674(1990).
Dilella A.G.,et al.Biochemistry 30:8512-8517(1991).
Peattie D.A.,et al.Gene 150:251-257(1994).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP21438c
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