|Other Names||Mastermind-like protein 2, Mam-2, MAML2, KIAA1819|
|Target/Specificity||The synthetic peptide sequence is selected from aa 780-794 of HUMAN MAML2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.|
|Cellular Location||Nucleus speckle. Note=Nuclear, in a punctate manner|
|Tissue Location||Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Tonon G.,et al.Nat. Genet. 33:208-213(2003).
Tonon G.,et al.Nat. Genet. 33:408-408(2003).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Taylor T.D.,et al.Nature 440:497-500(2006).
Enlund F.,et al.Exp. Cell Res. 292:21-28(2004).
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