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MAML2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q8IZL2
Additional Information
Gene ID 84441
Other Names Mastermind-like protein 2, Mam-2, MAML2, KIAA1819
Target/Specificity The synthetic peptide sequence is selected from aa 780-794 of HUMAN MAML2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAML2
Synonyms KIAA1819
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Cellular Location Nucleus speckle. Note=Nuclear, in a punctate manner
Tissue Location Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle
Research Areas
Citations (0)

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Background

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.

References

Tonon G.,et al.Nat. Genet. 33:208-213(2003).
Tonon G.,et al.Nat. Genet. 33:408-408(2003).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Taylor T.D.,et al.Nature 440:497-500(2006).
Enlund F.,et al.Exp. Cell Res. 292:21-28(2004).

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$ 80.00
$ 99.00
Cat# BP21469c
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