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NGEF Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8N5V2
Additional Information
Gene ID 25791
Other Names Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF
Target/Specificity The synthetic peptide sequence is selected from aa 187-200 of HUMAN NGEF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NGEF
Function Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Cellular Location Cytoplasm. Membrane. Cell projection, growth cone Note=Associated with membranes. Localizes to axonal growth cones (By similarity).
Tissue Location Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus Also detected in lung.
Research Areas
Citations (0)

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Background

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Rodrigues N.R.,et al.Genomics 65:53-61(2000).

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$ 80.00
Cat# BP21608a
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