TMPRSS11D Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O60235 |
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Gene ID | 9407 |
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Other Names | Transmembrane protease serine 11D, 3421-, Airway trypsin-like protease, Transmembrane protease serine 11D non-catalytic chain, Transmembrane protease serine 11D catalytic chain, TMPRSS11D, HAT |
Target/Specificity | The synthetic peptide sequence is selected from aa 104-119 of HUMAN TMPRSS11D |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMPRSS11D |
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Synonyms | HAT |
Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. |
Cellular Location | Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted |
Tissue Location | Located in the cells of the submucosal serous glands of the bronchi and trachea |
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Background
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.
References
Yamaoka K.,et al.J. Biol. Chem. 273:11895-11901(1998).
Yasuoka S.,et al.Am. J. Respir. Cell Mol. Biol. 16:300-308(1997).
Bertram S.,et al.J. Virol. 87:6150-6160(2013).
Heurich A.,et al.J. Virol. 88:1293-1307(2014).
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