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(DANRE) hspa8 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q90473
Additional Information
Other Names Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8, hspa8, hsc70
Target/Specificity The synthetic peptide sequence is selected from aa 548-562 of HUMAN hspa8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name hspa8
Synonyms hsc70
Function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
Research Areas
Citations (0)

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References

Graser R.T.,et al.Genetica 98:273-276(1996).

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$ 80.00
Cat# BP21747b
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