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MICB Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q29980 |
|---|
| Gene ID | 4277 |
|---|---|
| Other Names | MHC class I polypeptide-related sequence B, MIC-B, MICB {ECO:0000312|EMBL:CAA628231} |
| Target/Specificity | The synthetic peptide sequence is selected from aa 85-98 of HUMAN MICB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MICB {ECO:0000312|EMBL:CAA62823.1} |
|---|---|
| Function | Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983} Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710} |
| Tissue Location | Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
References
Bahram S.,et al.Immunogenetics 43:230-233(1996).
Bahram S.,et al.Immunogenetics 45:161-162(1996).
Martinez-Borra J.,et al.Hum. Immunol. 68:705-707(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hirakawa M.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
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