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MICB Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q29980
Additional Information
Gene ID 4277
Other Names MHC class I polypeptide-related sequence B, MIC-B, MICB {ECO:0000312|EMBL:CAA628231}
Target/Specificity The synthetic peptide sequence is selected from aa 85-98 of HUMAN MICB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MICB {ECO:0000312|EMBL:CAA62823.1}
Function Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710}
Tissue Location Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue
Research Areas
Citations (0)

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Background

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

References

Bahram S.,et al.Immunogenetics 43:230-233(1996).
Bahram S.,et al.Immunogenetics 45:161-162(1996).
Martinez-Borra J.,et al.Hum. Immunol. 68:705-707(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hirakawa M.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP21778a
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