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NUGGC Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q68CJ6
Additional Information
Gene ID 389643
Other Names Nuclear GTPase SLIP-GC, 361-, Speckled-like pattern in the germinal center, NUGGC, C8orf80
Target/Specificity The synthetic peptide sequence is selected from aa 299-311 of HUMAN NUGGC
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUGGC
Synonyms C8orf80
Function Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).
Cellular Location Nucleus speckle
Tissue Location Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell
Research Areas
Citations (0)

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Background

Plays a role as replication-related GTPase protein in germinal center B-cell.

References

Nusbaum C.,et al.Nature 439:331-335(2006).
Yamada S.,et al.Oncogene 23:5901-5911(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Richter K.,et al.J. Biol. Chem. 284:30652-30661(2009).

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$ 80.00
Cat# BP21865c
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