|Other Names||Nuclear GTPase SLIP-GC, 361-, Speckled-like pattern in the germinal center, NUGGC, C8orf80|
|Target/Specificity||The synthetic peptide sequence is selected from aa 299-311 of HUMAN NUGGC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).|
|Cellular Location||Nucleus speckle|
|Tissue Location||Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role as replication-related GTPase protein in germinal center B-cell.
Nusbaum C.,et al.Nature 439:331-335(2006).
Yamada S.,et al.Oncogene 23:5901-5911(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Richter K.,et al.J. Biol. Chem. 284:30652-30661(2009).
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