|Other Names||Deoxyribonuclease-1-like 2, 3.1.21.-, DNase I homolog protein DHP1, Deoxyribonuclease I-like 2, DNase I-like 2, DNASE1L2, DHP1, DNAS1L2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 219-229 of HUMAN DNASE1L2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.|
|Cellular Location||Cytoplasm. Secreted|
|Tissue Location||Preferentially expressed in the skin and up- regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum|
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Provided below are standard protocols that you may find useful for product applications.
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
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Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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