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ROBO1 Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q9Y6N7
Additional Information
Gene ID 6091
Other Names Roundabout homolog 1, Deleted in U twenty twenty, H-Robo-1, ROBO1, DUTT1
Target/Specificity The synthetic peptide sequence is selected from aa 1117-1130 of HUMAN ROBO1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ROBO1
Synonyms DUTT1
Function Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP- bound RHOA (PubMed:26529257). May be required for lung development (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:O89026}. Note=Detected at growth cones in thalamus neurons. {ECO:0000250|UniProtKB:O89026}
Tissue Location Widely expressed, with exception of kidney.
Research Areas
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Background

Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.

References

Kidd T.,et al.Cell 92:205-215(1998).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Brose K.,et al.Cell 96:795-806(1999).

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$ 80.00
Cat# BP21950b
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