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PSME4 Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q14997
Other Accession F1MKX4
Additional Information
Gene ID 23198
Other Names Proteasome activator complex subunit 4, Proteasome activator PA200, PSME4, KIAA0077
Target/Specificity The synthetic peptide sequence is selected from aa 523-535 of HUMAN PSME4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSME4
Synonyms KIAA0077
Function Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Cellular Location Cytoplasm, cytosol. Nucleus. Nucleus speckle Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2)
Research Areas
Citations (0)

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Background

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

References

Blickwedehl J.,et al.Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
Nomura N.,et al.DNA Res. 1:223-229(1994).
Ustrell V.,et al.EMBO J. 21:3516-3525(2002).
Wang X.,et al.Biochemistry 46:3553-3565(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 80.00
Cat# BP21982a
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