|Other Names||Ribosomal L1 domain-containing protein 1, CATX-11, Cellular senescence-inhibited gene protein, Protein PBK1, RSL1D1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 475-485 of HUMAN RSL1D1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.|
|Cellular Location||Nucleus, nucleolus Note=Colocalizes with ING1 in the nucleolus after UV stress|
|Tissue Location||Expressed at high intensities in the heart, skeletal muscle, and placenta.|
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Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.
Huch G.,et al.Placenta 19:557-567(1998).
Petroziello J.,et al.Oncogene 23:7734-7745(2004).
Guo S.-Z.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
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