|Other Names||Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB|
|Target/Specificity||The synthetic peptide sequence is selected from aa 18-29 of HUMAN KLB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).|
|Cellular Location||Cell membrane; Single-pass type III membrane protein|
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Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Hayashi A.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.J. Biol. Chem. 283:33304-33309(2008).
Micanovic R.,et al.J. Cell. Physiol. 219:227-234(2009).
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