|Other Names||5'(3')-deoxyribonucleotidase, mitochondrial, 5', 3'-nucleotidase, mitochondrial, 3.1.3.-, Deoxy-5'-nucleotidase 2, dNT-2, NT5M, DNT2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 79-90 of HUMAN NT5M|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.|
|Tissue Location||Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Rampazzo C.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:8239-8244(2000).
Rinaldo-Matthis A.,et al.Nat. Struct. Biol. 9:779-787(2002).
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