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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   GPLD1 Antibody (C-term) Blocking Peptide   

GPLD1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P80108
Clone Names 3102412
Peptide ID 3102412
Additional Information
Gene ID 2822
Other Names Phosphatidylinositol-glycan-specific phospholipase D, PI-G PLD, Glycoprotein phospholipase D, Glycosyl-phosphatidylinositol-specific phospholipase D, GPI-PLD, GPI-specific phospholipase D, GPLD1, PIGPLD1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2461b was selected from the C-term region of human GPLD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPLD1
Synonyms PIGPLD1
Function This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Cellular Location Secreted.
Research Areas
Citations (0)

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GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.


Tsang, T.C., et al., FASEB J. 6, A1922-A1922 (1992).

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$ 80.00
Cat# BP2461b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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