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HSF1 Sumoylation site Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q00613
Clone Names 2110405
Peptide ID 2110405
Additional Information
Gene ID 3297
Other Names Heat shock factor protein 1, HSF 1, Heat shock transcription factor 1, HSTF 1, HSF1, HSTF1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2501a is PLVRVKEEPPSPPQSPR, containing a predicted sumoylation site from the central region of human HSF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSF1
Synonyms HSTF1
Function DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules
Research Areas
Citations (0)

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Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress, HSF1 acquires DNA-binding ability and localizes to nuclear stress granules. SUMO modification of HSF1 converts HSF1 to the DNA-binding form. HSF1 colocalizes with SUMO-1 in nuclear stress granules, which is prevented by mutation of the HSF1 lysine targeted for sumoylation.


Hilgarth, et al., Biochem Biophys Res Commun. 2003 Mar 28;303(1):196-200.He, H., et al., J. Biol. Chem. 278(37):35465-35475 (2003).Wang, X., et al., Mol. Cell. Biol. 23(17):6013-6026 (2003).Ignatenko, N.A., et al., Exp. Cell Res. 288(1):1-8 (2003).Soncin, F., et al., Biochem. Biophys. Res. Commun. 303(2):700-706 (2003).

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$ 80.00
Cat# BP2501a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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