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HSF2 Sumoylation Site Antibody Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q03933
Clone Names 2110406
Peptide ID 2110406
Additional Information
Gene ID 3298
Other Names Heat shock factor protein 2, HSF 2, Heat shock transcription factor 2, HSTF 2, HSF2, HSTF2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2502a was selected from the region of a human HSF2 sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSF2
Synonyms HSTF2
Function DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation
Research Areas
Citations (0)

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Background

HSF2 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. The protein is found as a DNA-binding homotrimer in stressed or heat shocked cells, and otherwise found as a homodimer. HSF2 is cytoplasmic during normal growth and moves to the nucleus upon activation. Sumoylation of HSF2 hinders HSF2 DNA-binding activity, without affecting its oligomerization, and is an example of negative regulation of gene expression via sumoylation.

References

He, H., et al., J. Biol. Chem. 278(37):35465-35475 (2003).Nykanen, P., et al., Cell Stress Chaperones 6(4):377-385 (2001).Sarge, K.D., et al., Genes Dev. 5(10):1902-1911 (1991).Schuetz, T.J., et al., Proc. Natl. Acad. Sci. U.S.A. 88(16):6911-6915 (1991).

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$ 80.00
Cat# BP2502a
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