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FACL6 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UKU0
Other Accession ACSL6_HUMAN
Clone Names 3092106
Peptide ID 3092106
Additional Information
Gene ID 23305
Other Names Long-chain-fatty-acid--CoA ligase 6, Long-chain acyl-CoA synthetase 6, LACS 6, ACSL6, ACS2, FACL6, KIAA0837, LACS5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2537b was selected from the Center region of human FACL6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACSL6
Synonyms ACS2, FACL6, KIAA0837, LACS5
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Cellular Location Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein
Tissue Location Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
Research Areas
Citations (0)

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Background

FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5;12)(q31;p13) that involves ETV6 and ACSL6.

References

Yagasaki, F., et al., Genes Chromosomes Cancer 26(3):192-202 (1999).Nagase, T., et al., DNA Res. 5(6):355-364 (1998).Malhotra, K.T., et al., Biochem. J. 344 Pt 1, 135-143 (1999).

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$ 80.00
Cat# BP2537b
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