|Other Names||Rho guanine nucleotide exchange factor 9, Collybistin, Rac/Cdc42 guanine nucleotide exchange factor 9, Arhgef9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2713c was selected from the Center region of human Arhgef9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|
|Tissue Location||Detected in brain, throughout the gray matter. Detected at low levels in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.
Xiang,S., J. Mol. Biol. 359 (1), 35-46 (2006)Harvey,K., J. Neurosci. 24 (25), 5816-5826 (2004)Grosskreutz,Y., Biol. Chem. 382 (10), 1455-1462 (2001)Kins,S., Nat. Neurosci. 3 (1), 22-29 (2000)
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