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PIWIL1 (PIWI) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96J94
Clone Names 70920132
Additional Information
Gene ID 9271
Other Names Piwi-like protein 1, PIWIL1, HIWI
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2731a was selected from the N-term region of human PIWIL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HIWI
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.
Cellular Location Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis Also present in chromatoid body (By similarity).
Tissue Location Expressed in spermatocytes and spermatids. Also detected in prostate cancer (at protein level). Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells.
Research Areas
Citations (0)

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PIWIL1 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. This protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.


Taubert,H., Oncogene 26 (7), 1098-1100 (2007)Liu,X., Int. J. Cancer 118 (8), 1922-1929 (2006)Qiao,D., Oncogene 21 (25), 3988-3999 (2002)

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$ 80.00
Cat# BP2731a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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