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TRF (TERF1) Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P54274
Clone Names 80109166
Peptide ID 80109166
Additional Information
Gene ID 7013
Other Names Telomeric repeat-binding factor 1, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1, TERF1, PIN2, TRBF1, TRF, TRF1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2759b was selected from the C-term region of human TERF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TERF1
Synonyms PIN2, TRBF1, TRF, TRF1
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle
Tissue Location Highly expressed and ubiquitous. Isoform Pin2 predominates
Research Areas
Citations (0)

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TERF1 is a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus.


Kim,M.K., J. Biol. Chem. 283 (20), 14144-14152 (2008)Etheridge,K.T., J. Biol. Chem. 283 (11), 6935-6941 (2008)Muramatsu,Y., Exp. Cell Res. 314 (5), 1115-1124 (2008)

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$ 80.00
Cat# BP2759b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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