|Other Names||UTP--glucose-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, UGPase, UGP2, UGP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2760a was selected from the N-term region of human UGP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a central role as a glucosyl donor in cellular metabolic pathways.|
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Provided below are standard protocols that you may find useful for product applications.
UGP2 is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue,UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme.
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)Wistow,G., (er) Mol. Vis. 8, 205-220 (2002)Chang,H.Y., Eur. J. Biochem. 236 (2), 723-728 (1996)
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