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ZIC3 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession O60481
Other Accession NP_003404.1
Additional Information
Gene ID 7547
Other Names Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203
Target/Specificity The synthetic peptide sequence is selected from aa 254-267 of HUMAN ZIC3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZIC3
Synonyms ZNF203
Function Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Cellular Location Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.
Research Areas
Citations (0)

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This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.


Hatayama, M., et al. Hum. Mol. Genet. 17(22):3459-3473(2008)
Zhu, L., et al. Hum. Mutat. 29(1):99-105(2008)
Zhu, L., et al. Hum. Mol. Genet. 16(14):1649-1660(2007)
Chhin, B., et al. Hum. Mutat. 28(6):563-570(2007)
Bedard, J.E., et al. Hum. Mol. Genet. 16(2):187-198(2007)
Zhu, H., et al. Am. J. Med. Genet. A 116A (4), 414-415 (2003) :
Koyabu, Y., et al. J. Biol. Chem. 276(10):6889-6892(2001)
Klootwijk, R., et al. Hum. Mol. Genet. 9(11):1615-1622(2000)
Gebbia, M., et al. Nat. Genet. 17(3):305-308(1997)
Casey, B., et al. Nat. Genet. 5(4):403-407(1993)

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$ 80.00
Cat# BP2761c
Availability: 2 weeks
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