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ZIC3 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60481 |
|---|---|
| Other Accession | NP_003404.1 |
| Gene ID | 7547 |
|---|---|
| Other Names | Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 254-267 of HUMAN ZIC3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZIC3 |
|---|---|
| Synonyms | ZNF203 |
| Function | Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC- 3'. |
| Cellular Location | Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity) Translocation to the nucleus requires KPNA1 or KPNA6. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
References
Hatayama, M., et al. Hum. Mol. Genet. 17(22):3459-3473(2008)
Zhu, L., et al. Hum. Mutat. 29(1):99-105(2008)
Zhu, L., et al. Hum. Mol. Genet. 16(14):1649-1660(2007)
Chhin, B., et al. Hum. Mutat. 28(6):563-570(2007)
Bedard, J.E., et al. Hum. Mol. Genet. 16(2):187-198(2007)
Zhu, H., et al. Am. J. Med. Genet. A 116A (4), 414-415 (2003) :
Koyabu, Y., et al. J. Biol. Chem. 276(10):6889-6892(2001)
Klootwijk, R., et al. Hum. Mol. Genet. 9(11):1615-1622(2000)
Gebbia, M., et al. Nat. Genet. 17(3):305-308(1997)
Casey, B., et al. Nat. Genet. 5(4):403-407(1993)
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