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MTHFD1 Antibody (Center P550) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P11586
Other Accession NP_005947
Clone Names 80513218
Peptide ID 80513218
Additional Information
Gene ID 4522
Other Names C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase, Methylenetetrahydrofolate dehydrogenase, Methenyltetrahydrofolate cyclohydrolase, Formyltetrahydrofolate synthetase, C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed, MTHFD1, MTHFC, MTHFD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2788f was selected from the Center region of human MTHFD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTHFD1
Synonyms MTHFC, MTHFD
Cellular Location Cytoplasm.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

MTHFD1 is a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.

References

Ivanov,A., J Am Diet Assoc 109 (2), 313-318 (2009)Schmidt A., Biochemistry 39:6325-6335(2000)Hol F.A., Clin. Genet. 53:119-125(1998)

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$ 80.00
Cat# BP2788f
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