|Other Names||Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2792a was selected from the N-term region of human M6PR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.|
|Cellular Location||Lysosome membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.
Perez-Victoria,F.J., Mol. Biol. Cell 19 (6), 2350-2362 (2008)Mari,M., Traffic 9 (3), 380-393 (2008)Lemansky,P., J. Leukoc. Biol. 81 (4), 1149-1158 (2007)Chen,J.J., Cell 119 (7), 915-926 (2004)
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