|Other Names||General transcription factor IIH subunit 2, Basic transcription factor 2 44 kDa subunit, BTF2 p44, General transcription factor IIH polypeptide 2, TFIIH basal transcription factor complex p44 subunit, GTF2H2, BTF2P44|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2794a was selected from the N-term region of human GTF2H2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter.|
|Tissue Location||Widely expressed, with higher expression in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
GTF2H2 is the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair.
Ren,P., Am. J. Respir. Crit. Care Med. 175 (11), 1151-1157 (2007)Kellenberger,E., J. Biol. Chem. 280 (21), 20785-20792 (2005)
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