|Other Names||Small nuclear ribonucleoprotein F, snRNP-F, Sm protein F, Sm-F, SmF, SNRPF, PBSCF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2815c was selected from the Center region of human SNRPF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes|
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Provided below are standard protocols that you may find useful for product applications.
SNRPF is associated with snRNP U1, U2, U4/U6 and U5.
Ma,Y., Structure 13 (6), 883-892 (2005)Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)Hermann,H., EMBO J. 14 (9), 2076-2088 (1995)
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