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PFN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P07737
Clone Names 80522094
Peptide ID 80522094
Additional Information
Gene ID 5216
Other Names Profilin-1, Epididymis tissue protein Li 184a, Profilin I, PFN1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2837b was selected from the C-term region of human PFN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PFN1
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Expressed in epididymis (at protein level).
Research Areas
Citations (0)

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PFN1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of PFN1 gene is associated with Miller-Dieker syndrome.


Shao,J., Mol. Cell. Biol. 28 (17), 5196-5208 (2008)Burnett,B.G., Neurobiol. Dis. 30 (3), 365-374 (2008)Gieselmann,R., Eur. J. Biochem. 229 (3), 621-628 (1995)

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$ 80.00
Cat# BP2837b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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