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DHCR24 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15392
Clone Names 80317161
Peptide ID 80317161
Additional Information
Gene ID 1718
Other Names Delta(24)-sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2840a was selected from the N-term region of human DHCR24. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHCR24
Synonyms KIAA0018
Function Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein
Tissue Location Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
Research Areas
Citations (0)

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DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.


Wang,Y., Mol. Pharmacol. 74 (6), 1716-1721 (2008)Bonaccorsi,L., Lab. Invest. 88 (10), 1049-1056 (2008)Cecchi,C., J. Cell. Mol. Med. 12 (5B), 1990-2002 (2008)

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$ 80.00
Cat# BP2840a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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