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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CXADR Antibody (N-term) Blocking Peptide   

CXADR Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P78310
Clone Names 80317153
Peptide ID 80317153
Additional Information
Gene ID 1525
Other Names Coxsackievirus and adenovirus receptor, CAR, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR, CAR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2852a was selected from the N-term region of human CXADR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CAR
Function Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface Isoform 3: Secreted. Isoform 5: Secreted.
Tissue Location Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
Research Areas
Citations (0)

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CXADR is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses.


Tomko R.P., Xu R., Philipson L.Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997) Bergelson J.M., Cunningham J.A., Droguett G., science 275:1320-1323(1997)Bowles K.R., Gibson J., Wu J., Shaffer L.G.,Hum. Genet. 105:354-359(1999)

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$ 80.00
Cat# BP2852a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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