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CYP27A1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q02318
Clone Names 80305185
Peptide ID 80305185
Additional Information
Gene ID 1593
Other Names Sterol 26-hydroxylase, mitochondrial, 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase, Cytochrome P-450C27/25, Cytochrome P450 27, Sterol 27-hydroxylase, Vitamin D(3) 25-hydroxylase, CYP27A1, CYP27
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2853a was selected from the N-term region of human CYP27A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP27A1
Synonyms CYP27
Function Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity.
Cellular Location Mitochondrion membrane.
Research Areas
Citations (0)

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Background

CYP27A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in CYP27A1 gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

References

Cali J.J., Russell D.W.J. Biol. Chem. 266:7774-7778(1991)Guo Y.-D., Strugnell S., Back D.W., Jones G.Proc. Natl. Acad. Sci. U.S.A. 90:8668-8672(1993)Chen W., Kubota S., Kim K.-S., Cheng J., Kuriyama M.,J. Lipid Res. 38:870-879(1997) Chen W., Kubota S., Ujike H., Ishihara T.Biochemistry 37:15050-15056(1998)

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$ 80.00
Cat# BP2853a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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