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TK1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04183 |
|---|---|
| Clone Names | 80612071 |
| Gene ID | 7083 |
|---|---|
| Other Names | Thymidine kinase, cytosolic, TK1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2866c was selected from the Center region of human TK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TK1 (HGNC:11830) |
|---|---|
| Function | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c- azido-3c-deoxythymidine (AZT) (PubMed:22385435). |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TK1 catalyzes the activity:ATP + thymidine = ADP + thymidine 5'-phosphate.
References
Bradshaw H.D. Jr., Deininger P.L.Mol. Cell. Biol. 4:2316-2320(1984) Flemington E., Bradshaw H.D. Jr., Traina-Dorge V., Slagel V., Deininger P.L.Gene 52:267-277(1987)Kreidberg J.A., Kelly T.J.Mol. Cell. Biol. 6:2903-2909(1986)
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