|Other Names||Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, p38, AHSA1, C14orf3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2892a was selected from the N-term region of human AHSA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum|
|Tissue Location||Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
AHSA1 is a cochaperone that stimulates HSP90 ATPase activity. This protein may affect a step in the endoplasmic reticulum to Golgi trafficking.
Wang,X.,etc,Cell 127 (4), 803-815 (2006)Panaretou,B., etc,Mol. Cell 10 (6), 1307-1318 (2002)
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