|Other Names||WD repeat-containing protein 1, Actin-interacting protein 1, AIP1, NORI-1, WDR1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2919b was selected from the C-term region of human WDR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, podosome|
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Provided below are standard protocols that you may find useful for product applications.
WDR1 is a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. This protein may help induce the disassembly of actin filaments.
McArdle,P.F., et.al., Arthritis Rheum. 58 (9), 2874-2881 (2008)
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