YWHAH Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q04917 |
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Clone Names | 90121055 |
Gene ID | 7533 |
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Other Names | 14-3-3 protein eta, Protein AS1, YWHAH, YWHA1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2928a was selected from the N-term region of human YWHAH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | YWHAH |
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Synonyms | YWHA1 |
Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. |
Tissue Location | Expressed mainly in the brain and present in other tissues albeit at lower levels |
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Provided below are standard protocols that you may find useful for product applications.
Background
YWHAH belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs.
References
Martins-de-Souza,D.,et.al., J. Neural Transm. 116 (3), 275-289 (2009)
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