|Other Names||14-3-3 protein eta, Protein AS1, YWHAH, YWHA1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2928b was selected from the C-term region of human YWHAH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|
|Tissue Location||Expressed mainly in the brain and present in other tissues albeit at lower levels|
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Provided below are standard protocols that you may find useful for product applications.
YWHAH belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs.
Martins-de-Souza,D.,et.al., J. Neural Transm. 116 (3), 275-289 (2009)
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