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Phospho-14-3-3-T232 Antibody Blocking Peptide

Synthetic peptide

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United States
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Ordering Information
Catalog # Size Availability Price  
BP3001a 0.1 mg In Stock $ 45.00 Add to cart
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Phospho-14-3-3-T232 Antibody Blocking Peptide - Product info

Primary AccessionP62258
Clone Names4110209

Phospho-14-3-3-T232 Antibody Blocking Peptide - Additional info

Gene ID 7531
Target/Specificity
The synthetic peptide sequence used to generate the antibody AP3001a was selected from the region of human Phospho-14-3-3-T232. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Precautions
This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Phospho-14-3-3-T232 Antibody Blocking Peptide - Protein Information

Name YWHAE
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Cellular Location
Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Phospho-14-3-3-T232 Antibody Blocking Peptide - Related products

BP10671b: YWHAE Antibody (C-term) blocking peptides

BP3000a: Phospho-14-3-3-S58 Antibody Blocking Peptide

BP5837a: YWHAE Antibody (N-term) Blocking peptide

AJ1001c: 14-3-3E Antibody

Phospho-14-3-3-T232 Antibody Blocking Peptide - Research Areas

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

The 14-3-3 family of proteins mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

REFERENCES

Urschel, S., et al., J. Biol. Chem. 280(17):16987-16993 (2005).Yanagi, M., et al., J. Hum. Genet. 50(4):210-216 (2005).Wang, X., et al., J. Biol. Chem. 279(47):49460-49469 (2004).Clark, K.L., et al., J. Biol. Chem. 279(19):19401-19406 (2004).Wang, X., et al., Mol. Cell. Biol. 23(17):6013-6026 (2003).