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Phospho-14-3-3-T232 Antibody Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP3001a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Phospho-14-3-3-T232 Antibody Blocking Peptide - Product info | |
| Primary Accession | P62258 |
| Clone Names | 4110209 |
| Calculated MW | 29174 Da |
Phospho-14-3-3-T232 Antibody Blocking Peptide - Additional info | |
| Gene ID 7531 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP3001a was selected from the region of human Phospho-14-3-3-T232. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
Phospho-14-3-3-T232 Antibody Blocking Peptide - Protein Information | |
| Name YWHAE | |
| Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | |
| Cellular Location Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV | |
Phospho-14-3-3-T232 Antibody Blocking Peptide - Related products
AP10671b: YWHAE Antibody (C-term)
AP3000a: Phospho-YWHAE-pS58 Antibody
AP3001a: Phospho-YWHAE-pT232 Antibody
AP5837a: YWHAE Antibody (N-term)
RI15774: YWHAE predesign siRNA
BP3000a: Phospho-14-3-3-S58 Antibody Blocking Peptide
BP3001a: Phospho-14-3-3-T232 Antibody Blocking Peptide
Phospho-14-3-3-T232 Antibody Blocking Peptide - Research Areas
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BACKGROUND
The 14-3-3 family of proteins mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.
REFERENCES
Urschel, S., et al., J. Biol. Chem. 280(17):16987-16993 (2005).Yanagi, M., et al., J. Hum. Genet. 50(4):210-216 (2005).Wang, X., et al., J. Biol. Chem. 279(47):49460-49469 (2004).Clark, K.L., et al., J. Biol. Chem. 279(19):19401-19406 (2004).Wang, X., et al., Mol. Cell. Biol. 23(17):6013-6026 (2003).
