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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Phospho-14-3-3-T232 Antibody Blocking Peptide   

Phospho-14-3-3-T232 Antibody Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P62258
Clone Names 4110209
Additional Information
Gene ID 7531
Other Names 14-3-3 protein epsilon, 14-3-3E, YWHAE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP3001a was selected from the region of human Phospho-14-3-3-T232. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Protein Information
Name YWHAE
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Cellular Location Cytoplasm. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)

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Background

The 14-3-3 family of proteins mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

References

Urschel, S., et al., J. Biol. Chem. 280(17):16987-16993 (2005).Yanagi, M., et al., J. Hum. Genet. 50(4):210-216 (2005).Wang, X., et al., J. Biol. Chem. 279(47):49460-49469 (2004).Clark, K.L., et al., J. Biol. Chem. 279(19):19401-19406 (2004).Wang, X., et al., Mol. Cell. Biol. 23(17):6013-6026 (2003).

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Cat# BP3001a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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